Human coronavirus data from four clinical trials of masks and respirators

Human coronavirus data from four clinical trials of masks and respirators

Blog Article

There are few published data on the efficacy of masks or respirators against coronavirus infections.This is an important research question to inform the response to the COVID-19 epidemic.The transmission modes of human coronaviruses are similar, thought to be by droplet, contact, and sometimes airborne routes.

There are several randomized silver lining herbs kidney support clinical trials of masks and respirators, but most used clinical endpoints or tested only for influenza.In four trials that we conducted, we tested for human coronaviruses, but only composite viral endpoints were reported in the trials.We reviewed and analyzed the coronavirus data from four of our trials.

Laboratory-confirmed coronavirus infections were identified in our community household trial (one case), health worker trials (eight cases), and trial of mask use by sick patients (19 cases).No coronavirus infections were transmitted in households to parents who wore P2 or surgical masks, but one child with coronavirus infection transmitted infection to a parent in the control arm.No transmissions to close contacts occurred when worn by sick patients with coronavirus infections.

There was a higher risk of coronavirus infection in HCWs who wore a mask compared to a respirator, but the difference was not statistically significant.These are the only available clinical trial data on coronavirus infections associated with mask or respirator use.More clinical trials are needed to assess the efficacy of respiratory click here protection against coronavirus infections.